Solid-phase synthesis of peptide-viologen conjugates.
نویسندگان
چکیده
This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 75 6 شماره
صفحات -
تاریخ انتشار 2010